A great part of being a designer is learning about complex issues and working with smart and logical people. A common issue is trying to communicate a difficult and unappealing subject, such as prostate cancer, in a way that invites the audience. It's important to be true to the subject, but detailed images of surgery tend to not be good for publication covers.
Upjohn Pharmaceuticals produced Scope magazine in the 1940s and 1950s. Designers such as Will Burtin and Lester Beall designed arresting and seductive covers. These offer an alternative to the high resolution four-color digital photography that is the default medium for everyone this day. They may look light and playful, as if the designer threw it together on a sunny afternoon. But, guess what, it probably took some time. No doubt, Beall and Burtin slaved away in a dark Dickensian hovel as it snowed outside toiling to meet the deadlines.